ABG interpretation uses arterial blood values to evaluate acid-base balance, ventilation, and oxygenation. This cheat sheet helps students follow a clear sequence instead of guessing from isolated numbers. It is useful for connecting respiratory physiology, kidney function, and clinical decision making.
The goal is to identify the main disorder, check compensation, and notice oxygen problems quickly.
The most important values are pH, PaCO2, HCO3-, and PaO2. Low pH means acidemia, high pH means alkalemia, PaCO2 shows the respiratory acid effect, and HCO3- shows the metabolic base effect. Compensation occurs when the lungs or kidneys shift PaCO2 or HCO3- to reduce the pH problem.
Oxygenation is checked mainly with PaO2 and oxygen saturation, while the anion gap helps classify metabolic acidosis.
Key Facts
- Normal arterial pH is 7.35 to 7.45, with pH less than 7.35 showing acidemia and pH greater than 7.45 showing alkalemia.
- Normal PaCO2 is 35 to 45 mmHg, and PaCO2 acts as an acid because CO2 combines with water to form carbonic acid.
- Normal HCO3- is 22 to 26 mEq/L, and HCO3- acts as a base controlled mainly by the kidneys.
- Respiratory acidosis has low pH and high PaCO2, while respiratory alkalosis has high pH and low PaCO2.
- Metabolic acidosis has low pH and low HCO3-, while metabolic alkalosis has high pH and high HCO3-.
- If pH and PaCO2 move in opposite directions, the primary problem is usually respiratory; if pH and HCO3- move in the same direction, the primary problem is usually metabolic.
- Anion gap = Na+ - (Cl- + HCO3-), and a typical normal range is about 8 to 12 mEq/L without potassium.
- Compensation changes the non-primary value, but full correction of pH into the normal range may indicate a mixed disorder or a fully compensated condition.
Vocabulary
- ABG
- An arterial blood gas is a blood test that measures pH, carbon dioxide, bicarbonate, oxygen, and related values in arterial blood.
- Acidemia
- Acidemia means the blood pH is below 7.35.
- Alkalemia
- Alkalemia means the blood pH is above 7.45.
- PaCO2
- PaCO2 is the partial pressure of carbon dioxide in arterial blood and reflects ventilation and the respiratory side of acid-base balance.
- HCO3-
- HCO3- is bicarbonate, a major blood buffer that reflects the metabolic or kidney side of acid-base balance.
- Anion Gap
- The anion gap estimates unmeasured acids in the blood using the formula anion gap = Na+ - (Cl- + HCO3-).
Common Mistakes to Avoid
- Calling every abnormal pH a complete diagnosis is wrong because the pH only tells whether the blood is acidic or alkaline, not the cause.
- Ignoring PaCO2 direction is wrong because high PaCO2 causes acidosis and low PaCO2 causes alkalosis through the respiratory system.
- Treating compensation as the primary disorder is wrong because compensation is the body’s response, not the original acid-base problem.
- Forgetting units and normal ranges is wrong because PaCO2 in mmHg and HCO3- in mEq/L must be compared to their own reference ranges.
- Skipping oxygenation is wrong because an ABG can show a clear acid-base pattern while still revealing dangerous hypoxemia through low PaO2.
Practice Questions
- 1 An ABG shows pH 7.28, PaCO2 58 mmHg, and HCO3- 25 mEq/L. Identify the primary acid-base disorder.
- 2 An ABG shows pH 7.50, PaCO2 30 mmHg, and HCO3- 24 mEq/L. Identify the primary acid-base disorder.
- 3 Calculate the anion gap for Na+ 140 mEq/L, Cl- 104 mEq/L, and HCO3- 12 mEq/L, then state whether it is elevated if normal is 8 to 12 mEq/L.
- 4 A patient has abnormal pH, abnormal PaCO2, and abnormal HCO3-. Explain how you would decide which change is primary and which change is compensation.