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Biology Grades 9–12

Genetics & Evolution Mission

Trace information from DNA to phenotype — Punnett squares, gene expression, Hardy-Weinberg equilibrium, and molecular evolution.

8 activities · Work through in order for a complete lesson arc

1

Genetics & Punnett Square Calculator

Generate Punnett squares for monohybrid, dihybrid, incomplete dominance, and sex-linked crosses. Color-coded SVG grid with genotype and phenotype ratios and step-by-step analysis.

2

DNA/RNA Codon Translator

Transcribe DNA to mRNA and translate codons into amino acid chains. Beautiful sequence diagram with color-coded nucleotides, codon brackets, amino acid pills, full 64-codon table, and reverse translation.

3

DNA Sequence Explorer

Align DNA sequences with Needleman-Wunsch and Smith-Waterman algorithms. Translate codons, introduce mutations, compute Jukes-Cantor distances, and build UPGMA phylogenetic trees.

4

Gene Expression Explorer

Simulate lac and trp operon regulation, eukaryotic gene expression, and signal-to-expression cascades. Toggle inducers, repressors, and enhancers to see how transcription rates and protein levels respond.

5

Hardy-Weinberg Equilibrium Calculator

Calculate allele and genotype frequencies, test populations for HW equilibrium with chi-square, and simulate evolutionary forces like selection, drift, mutation, and migration over generations.

Model how allele frequencies change under selection.

6

Mitosis & Meiosis Lab

Count cells in different mitotic phases to calculate mitotic index. Estimate phase durations from proportions, compare cell cycle timing, and test phase distribution with chi-square analysis

7

Hardy-Weinberg & Natural Selection Lab

Simulate allele frequency changes across generations under selection, drift, mutation, and migration. Test Hardy-Weinberg equilibrium with chi-square analysis and explore how evolutionary forces reshape populations

8

Molecular Evolution Lab

Compare hemoglobin DNA sequences across species. Measure percent identity, compute Jukes-Cantor distances, build phylogenetic trees, and study how mutations affect protein translation

Capstone — compare DNA sequences across species.